Use Gzip Compression

While not necessarily a server performance tip (since you might see CPU utilization go up), using gzip compression can decrease the number of bytes sent by your server. This gives the perception of faster pages and also cuts down on bandwidth usage. Depending on the data sent, how well it can be compressed, and whether the client browsers support it (IIS will only send gzip compressed content to clients that support gzip compression, such as Internet Explorer 6.0 and Firefox), your server can serve more requests per second. In fact, just about any time you can decrease the amount of data returned, you will increase requests per second.
The good news is that gzip compression is built into IIS 6.0 and is much better than the gzip compression used in IIS 5.0. Unfortunately, when attempting to turn on gzip compression in IIS 6.0, you may not be able to locate the setting on the properties dialog in IIS. The IIS team built awesome gzip capabilities into the server, but neglected to include an administrative UI for enabling it. To enable gzip compression, you have to spelunk into the innards of the XML configuration settings of IIS 6.0 (which isn't for the faint of heart). By the way, the credit goes to Scott Forsyth of OrcsWeb who helped me figure this out for the www.asp.net severs hosted by OrcsWeb.
Rather than include the procedure in this article, just read the article by Brad Wilson at IIS6 Compression. There's also a Knowledge Base article on enabling compression for ASPX, available at Enable ASPX Compression in IIS. It should be noted, however, that dynamic compression and kernel caching are mutually exclusive on IIS 6.0 due to some implementation details.